Temosure 250 Capsule is a pharmaceutical product widely used in the management of various medical conditions. It contains Temozolomide, an oral chemotherapy agent that is primarily indicated for the treatment of certain types of brain tumors. This article aims to provide a detailed overview of Temosure 250 Capsule, including its uses, dosage, side effects, and precautions.
Composition and Mechanism of Action
Active Ingredient: Temozolomide (250 mg)
Temozolomide is an alkylating agent that works by damaging the DNA of cancer cells, thereby inhibiting their growth and proliferation. It is particularly effective in treating malignant gliomas, including glioblastoma multiforme and anaplastic astrocytoma.
Indications
Temosure 250 Capsule is primarily prescribed for:
- Glioblastoma Multiforme: Both newly diagnosed and recurrent cases.
- Anaplastic Astrocytoma: Typically after the failure of other treatments.
- Melanoma: In certain cases, as part of combination therapy.
Dosage and Administration
The dosage of Temosure 20 Capsule is determined by the treating oncologist based on various factors such as the type and stage of cancer, patient’s body surface area, and overall health condition. It is crucial to follow the prescribed dosage regimen strictly.
General Dosage Guidelines:
- For Newly Diagnosed Glioblastoma: Typically, 75 mg/m² for 42 days along with radiotherapy, followed by maintenance therapy of 150-200 mg/m² for 5 days in a 28-day cycle.
- For Recurrent Anaplastic Astrocytoma: Usually, 150-200 mg/m² for 5 days in a 28-day cycle.
Administration Instructions
- Oral Administration: Take the capsule on an empty stomach, preferably at least one hour before or two hours after a meal.
- Consistency: Take the medication at the same time each day to maintain consistent blood levels.
- Swallow Whole: Do not open, crush, or chew the capsules.
Side Effects
Like all medications, Temosure 250 Capsule can cause side effects. Common side effects include:
- Nausea and Vomiting: Often managed with antiemetic medications.
- Fatigue and Weakness: Common but manageable with adequate rest and nutrition.
- Hair Loss: Temporary and reversible.
- Hematologic Toxicity: Decreased blood cell counts, which can lead to anemia, infections, or bleeding.
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